A commonly used Korean skincare ingredient may hold promise in the fight against antibiotic resistant bacteria, according to new research. Scientists have identified madecassic acid as a potential compound that could help develop future treatments for serious infections.
Researchers from the University of Kent, in collaboration with University College London, conducted the study. They combined computer based screening with laboratory testing to analyze the compound’s effects on harmful bacteria.
Plant based compound draws scientific attention
Madecassic acid comes from Centella asiatica, a medicinal plant widely used across Asia. The herb has a long history in traditional medicine and is also popular in skincare products for its soothing properties.
The study found that the compound has strong antibacterial activity. Researchers believe it could serve as a starting point for developing new medicines, especially as antimicrobial resistance continues to rise globally.
Health experts warn that drug resistant infections could cause millions of deaths in the coming decades. This has increased the urgency to find alternative treatments that can target resistant bacteria effectively.
How the compound works
Scientists discovered that madecassic acid targets a specific bacterial system known as the cytochrome bd complex. This system helps bacteria produce energy and survive during infection.
By binding to this protein complex, the compound disrupts the bacteria’s normal function. As a result, it prevents the growth of antibiotic resistant strains such as E coli.
Researchers highlighted that this system does not exist in humans or animals. Therefore, it may offer a safer target for developing treatments without harming healthy cells.
Modified versions show stronger results
The research team also explored modified versions of the compound. They extracted madecassic acid from plant samples and created several variations to test its effectiveness.
All modified versions successfully blocked bacterial growth. One variation showed stronger results and was able to kill bacteria at higher concentrations.
Scientists plan to continue refining these compounds to improve their effectiveness. Further studies will focus on their potential use in medical treatments.
Possible link to skincare benefits
The findings may also explain how madecassic acid interacts with the skin microbiome. Its antibacterial properties could contribute to its effectiveness in skincare products.
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Researchers believe this dual role highlights the broader potential of plant based compounds. The study adds to growing evidence that natural ingredients may play an important role in future medical advancements.
As research continues, madecassic acid could become a key focus in efforts to combat antibiotic resistance and develop new treatment options.
